Cardio-oncology & otherCohort study
Impact of SARS-CoV-2 infection on subclinical myocardial injury in the general population: the Trøndelag Health Study
- Prospective cohort study
- population-based
Authors' conclusion
In a large cohort of community dwellers, SARS-CoV-2 is associated with a higher probability of increasing concentrations of cTnI from before to after infection, reinforcing the role of SARS-CoV-2 infection in the development of chronic subclinical myocardial injury. In contrast, pre-existing chronic subclinical myocardial injury was not associated with increased risk of contracting SARS-CoV-2.
Study context
- Population
- General population participating in the Trøndelag Health Study, cardiac troponin I (cTnI) measured pre-pandemic (2018 to 2019) and post-pandemic (2021–2023)19,550 with post-pandemic measurement
- Participants
- 37,823 participants
- Exposure
- SARS-CoV-2 infection vs no infection
- Outcome
- Change in high-sensitivity cTnI from pre- to post-pandemic; association of pre-pandemic cTnI with incident SARS-CoV-2 infection
Main finding
As reported in the abstract
- Interim SARS-CoV-2 infection associated with higher post-pandemic cTnI and higher probability of increasing cTnI from pre- to post-pandemic (adjusted for confounders and pre-pandemic cTnI)
- Higher pre-pandemic cTnI associated with lower risk of contracting SARS-CoV-2
Observational data: associations, not effects.
Original publication
Impact of SARS-CoV-2 infection on subclinical myocardial injury in the general population: the Trøndelag Health Study. Eur J Prev Cardiol. Published 26 May 2026. doi:10.1093/eurjpc/zwag228
Summarised from the published abstract; every number is checked against it