Meta-analysis
Impact of semaglutide on limb events: a meta-analysis of randomized controlled trials
- Systematic review and meta-analysis of randomised trials
- random-effects model
- PRISMA
Authors' conclusion
This meta-analysis suggest that semaglutide is associated with a significant reduction in major limb events across diverse populations and treatment settings, supporting a potential protective effect on limb-related vascular safety.
Study context
- Population
- Individuals with T2DM and/or overweight or obesity
- Participants
- 51,557 individuals · 19 RCTs
- Comparison
- Semaglutide vs control
- Outcome
- Major limb events (revascularizations, amputations, peripheral artery disease (PAD) progression); prespecified safety outcomes in the original trials
Pooled result
Limb events
Odds ratio
0.70
95% CI 0.60–0.82
P < 0.0001
Semaglutide vs Control
OR 0.70 (95% CI 0.60–0.82); P < 0.0001
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Limb events, by subgroup — Semaglutide vs Control · diabetes | 0.70 (0.57–0.87) | P = 0.001 | |
| Limb events, by subgroup — Semaglutide vs Control · obesity | 0.71 (0.56–0.89) | P = 0.003 | |
| 0.512Odds ratio (log scale) |
| Outcome | Estimate | P value |
|---|---|---|
| Limb events, by subgroup — Semaglutide vs Control · oral formulation | 0.71 (95% CI 0.53–0.94) | P = 0.02 |
| Limb events, by subgroup — Semaglutide vs Control · subcutaneous 1.0 mg | 0.68 (95% CI 0.49–0.95) | P = 0.02 |
| Limb events, by subgroup — Semaglutide vs Control · subcutaneous 2.4 mg | 0.71 (95% CI 0.57–0.89) | P = 0.003 |
Limb events, by subgroup
- Benefit consistent regardless of background SGLT2 inhibitor use
Meta-regression
- No significant effect modification by age, BMI, HbA1c, follow-up duration or SGLT2i use
Original publication
Impact of semaglutide on limb events: a meta-analysis of randomized controlled trials. Eur J Prev Cardiol. Published 9 February 2026. doi:10.1093/eurjpc/zwag077
Summarised from the published abstract; every number is checked against it