Valvular & structural heart diseaseCohort study
Impact of Sievers morphology on fibro-calcific remodelling in severe bicuspid aortic valve stenosis: exploratory findings from sex-stratified analyses
- retrospective study
Authors' conclusion
In severe BAV stenosis, Sievers type 0 morphology is associated with higher fibrotic density than type 1, whereas calcific density is comparable; exploratory analyses suggest a potential sex-related difference that warrants further investigation in larger cohorts.
Study context
- Population
- Patients with severe bicuspid aortic valve (BAV) stenosis who underwent both echocardiography and cardiac computed tomography43.4% women · type 0 134 · type 1 110
- Participants
- 244 patients
- Exposure
- compare calcific and fibrotic remodelling between Sievers type 0 and type 1 BAV in severe aortic stenosis (AS)
- type 0n = 134
- type 1n = 110
Main finding
As reported in the abstract
Fibrotic density (overall cohort)
P < 0.001
Observational data: associations, not effects.
Further findings
Fibrotic density in women (exploratory sex-stratified analysis) · women · exploratory
P = 0.011
Calcific density (overall cohort)
- calcific density did not differ between groups
Fibrotic density in women (exploratory sex-stratified analysis)
- not statistically significant in men
Multivariable regression, women
- β
- −2.2
- 95% confidence interval
- −4.0 to −0.4
- P
- P = 0.016
- no significant associations were observed in men
Interaction between Sievers type and sex
- formal interaction testing not significant
- P = 0.140
Original publication
Impact of Sievers morphology on fibro-calcific remodelling in severe bicuspid aortic valve stenosis: exploratory findings from sex-stratified analyses. Eur Heart J Cardiovasc Imaging. Published 10 September 2026. doi:10.1093/ehjci/jeag250
Summarised from the published abstract; every number is checked against it