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Valvular & structural heart diseaseCohort study

Impact of Transcatheter Aortic Valve Replacement (TAVR) Failure Mechanism on Outcomes After Reintervention: From the EXPLANTORREDO-TAVR Registry

Circ Cardiovasc IntervPublished

  • Registry
  • 29 centers
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Authors' conclusion

SVD and NSVD failures had distinct valve types and reintervention timing, with SVD having a longer time to TAVR reintervention, but the failure mechanism did not impact reintervention type or clinical outcomes.

Study context

Population
Patients who underwent TAVR-explant or redo-TAVR for transcatheter aortic valve failure, 2009 to 2022; patients with endocarditis excludedunderwent TAVR-explant or redo-TAVR for transcatheter aortic valve failure, patients with endocarditis excluded · structural valve deterioration (SVD) 224 · nonstructural valve dysfunction (NSVD) 121
Participants
553 patients
Exposure
Patients with structural valve deterioration (SVD) were compared with those with nonstructural valve dysfunction (NSVD)
  • SVDn = 224
  • NSVDn = 121reference

Main finding

As reported in the abstract

Reintervention type

redo-TAVR

TAVR-explant

Observational data: associations, not effects.

Further findings

Balloon-expandable valves (mode of failure)

Non-balloon-expandable valves at redo-TAVR

Mortality, redo-TAVR · 30 days and 1 year

30 days

1 year

Mortality, TAVR-explant · 30 days and 1 year

30 days

1 year

Time to reintervention

Outcomehazard ratio (95% CI)P value
Risk-adjusted 3-year cumulative mortality · redo-TAVR · ref=NSVD1.30 (0.68–2.46)P = 0.43
Risk-adjusted 3-year cumulative mortality · TAVR-explant · ref=NSVD1.24 (0.64–2.41)P = 0.53
  • Balloon-expandable valves (mode of failure): P <0.001
  • Time to reintervention: P <0.001
  • Non-balloon-expandable valves at redo-TAVR: P =0.003
  • Mortality, redo-TAVR: 30 days P =1.00
  • Mortality, redo-TAVR: 1 year P =0.47
  • Mortality, TAVR-explant: 30 days P =0.63
  • Mortality, TAVR-explant: 1 year P =0.39

Baseline characteristics

Mean age
75.6±9.3 years
Women
42%

Original publication

Impact of TAVR Failure Mechanism on Outcomes After Reintervention: From the EXPLANTORREDO-TAVR Registry. Circ Cardiovasc Interv. Published 15 April 2026. doi:10.1161/circinterventions.125.016068
Read the original article ↗PubMedCite RIS · BibTeX

Summarised from the published abstract; every number is checked against it