Heart failure & cardiomyopathiesCohort study
Impact of the 2025 American Society of Echocardiography (ASE) Guidelines on the Classification of LV Diastolic Dysfunction in the Community: A Project Baseline Health Study
- Project Baseline Health Study
- community cohort
Authors' conclusion
The 2025 ASE recommendations identified more participants with LVDD than the 2016 algorithm without indeterminate classification or grading. LVDD by the 2025 classification was significantly associated with major adverse cardiovascular events, supporting the clinical relevance of the revised framework.
Study context
- Population
- Project Baseline Health Study participants who underwent comprehensive transthoracic echocardiographyparticipants who underwent comprehensive transthoracic echocardiography
- Participants
- 1,953 participants
- Exposure
- Left ventricular diastolic dysfunction (LVDD) classification by the 2025 ASE recommendations (fixed and age-specific thresholds) vs the 2016 ASE recommendations
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Event rates, reclassified as Grade 2 vs without LVDD
- Event rates, reclassified as Grade 2 vs without LVDD: P =0.02
Reclassification of participants indeterminate by the 2016 algorithm
- Indeterminate by the 2016 algorithm
- 119 (6.1%)
- Of the 119 indeterminate, reclassified as no LVDD by 2025
- 51.2%
- Of the 119 indeterminate, reclassified as Grade 2 LVDD by 2025
- 31.8%
Event-free survival, reclassified as no LVDD vs without LVDD
- Not statistically different
- P = 0.26
Major adverse cardiovascular events · median follow-up of 4.3 years
- Participants with major adverse cardiovascular events
- 98 (5.0%)
Association of LVDD with major adverse cardiovascular events
- LVDD by all classification approaches independently associated with major adverse cardiovascular events
- after adjustment for baseline risk factors
Baseline characteristics
- Median age
- 50.6 years (Q1-Q3: 36.3-64.2)
- Female
- 56.3%
- Hypertension
- 35.3%
- Diabetes
- 14.2%
Original publication
Summarised from the published abstract; every number is checked against it