Impact of Tricuspid Regurgitation on Outcomes After Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation: The PRIME-MR Registry

doi:10.1161/circinterventions.126.016634

Valvular & structural heart diseaseCohort study

Impact of Tricuspid Regurgitation on Outcomes After Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation: The PRIME-MR Registry

Circ Cardiovasc IntervPublished 11 Sep 2026

registry
25 international sites
2008 to 2022

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Authors' conclusion

In the PRIME-MR registry, 20% of patients with primary mitral regurgitation had severe TR at baseline. TR severity improved in 30% of TR≥Sev patients after successful M-TEER. The presence of TR≥Sev was independently associated with increased all-cause mortality at 2 years.

Study context

Population: Patients with severe primary mitral regurgitation undergoing mitral transcatheter edge-to-edge repair (M-TEER) with successful procedures (mitral regurgitation≤Moderate)analyzed, registry included 3083 patients · tricuspid regurgitation (TR)≥Sev 421 · TR≤Mod 1,734
Participants: 2,155 patients

Exposure: TR≤Moderate versus TR≥Severe
TR≥Sevn = 421
TR≤Modn = 1,734
Outcome: all-cause mortality
Follow-up: 2 years

Main finding

As reported in the abstract

Adjusted hazard ratio

2.01

95% CI 1.35–3.00

P < 0.001

By group

TR≥Sev29.6%

TR≤Mod19.6%

TR≤Moderate (TR≤Mod) versus TR≥Severe (TR≥Sev)

adjusted hazard ratio 2.01 (95% CI 1.35–3.00); P < 0.001

Observational data: associations, not effects.

Further findings

heart failure hospitalization · 2 years

TR≥Sev21.1%

TR≤Mod16.8%

Outcome	TR≥Sev	TR≤Mod
mortality, residual TR≥Sev vs TR≤Mod	Not reported in the abstract	19.9%

heart failure hospitalization: P Gray =0.018
mortality, residual TR≥Sev vs TR≤Mod: residual TR≥Sev 30.4%
mortality, residual TR≥Sev vs TR≤Mod: P log-rank =0.0037

Baseline characteristics, TR≥Sev vs TR≤Mod

New York Heart Association III/IV: P = 0.003
shorter 6-minute walk distance: P < 0.001
higher NT-proBNP: P < 0.001
higher creatinine: P < 0.001
higher pulmonary artery pressures: P < 0.001
atrial fibrillation: P < 0.001
more diuretics: P < 0.001

TR≥Sev decreased after successful M-TEER

TR≥Sev decreased: 30%

Original publication

Impact of Tricuspid Regurgitation on Outcomes After Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation: The PRIME-MR Registry. Circ Cardiovasc Interv. Published 11 September 2026. doi:10.1161/circinterventions.126.016634

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Summarised from the published abstract; every number is checked against it