Valvular & structural heart diseaseCohort study
Impact of Tricuspid Regurgitation on Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Valves
- Retrospective cohort study
- propensity-score matched
- registry-based (CMS-linked TVT Registry)
Authors' conclusion
Severe baseline and 30-day residual TR after TAVR are associated with increased mortality up to 3 years.
Study context
- Population
- Patients with AS undergoing transcatheter aortic valve replacement (TAVR) (balloon-expandable valves), CMS-linked TVT Registry84% mild, 13% moderate, 3% severe tricuspid regurgitation (TR)
- Participants
- 312,320 patients
- Exposure
- Severe vs moderate vs mild baseline TR in TAVR
- Outcome
- Mortality by baseline TR severity
- Follow-up
- Up to 3 years
Main finding
As reported in the abstract
Mortality by baseline TR
In-hospital mortality
1-year mortality
3-year mortality
Observational data: associations, not effects.
Further findings
1-year mortality by 30-day residual TR
| Outcome | Severe TR | Moderate TR | Mild TR |
|---|---|---|---|
| TR improvement to moderate or less at 30 days (severe baseline TR) · 30 days after TAVR | 76.4% | Not reported in the abstract | Not reported in the abstract |
- 1-year mortality by 30-day residual TR: P < 0.0001
Predictors of TR improvement after TAVR
- Baseline MR moderate or greater, preserved EF, higher aortic valve gradient and better kidney function predicted TR improvement
Original publication
Impact of Tricuspid Regurgitation on Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Valves. JACC Cardiovasc Interv. Published 26 August 2024. doi:10.1016/j.jcin.2024.07.005
Summarised from the published abstract; every number is checked against it