Impact of pre-admission physical activity on benefits of physiology-guided complete revascularization in older patients with myocardial infarction: insights from the FIRE trial
Authors' conclusion
In older patients with MI, pre-admission physical activity emerges as a robust and independent prognostic determinant. Physiology-guided complete revascularization stands out an effective strategy in reducing ischaemic adverse events, irrespective of pre-admission physical activity status.
Study context
- Population
- Patients aged ≥75 years with MI and multivessel disease
- Participants
- 1,445 patients
- Comparison
- Pre-admission physical activity (light or vigorous vs sedentary); physiology-guided complete revascularization vs culprit-only, by activity status
- Sedentaryn = 692reference
- Lightn = 560
- Vigorousn = 193
- Primary endpoint
- Composite of:
- Death
- MI
- Stroke
- Any revascularization
- Follow-up
- Within a year
Primary result
As reported in the abstract
Primary outcome by pre-admission physical activity
Each group vs sedentaryHazard ratio (95% CI)
Light
0.70(0.55–0.91)
Vigorous
0.14(0.07–0.91)
Secondary outcomes
Death, CV death or MI by physical activity
- Similar trends of reduced risk with light or vigorous activity vs sedentary
Original publication
Impact of pre-admission physical activity on benefits of physiology-guided complete revascularization in older patients with myocardial infarction: insights from the FIRE trial. Eur J Prev Cardiol. Published 7 March 2024. doi:10.
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