Impact of Smoking on Circulating Cardiac Troponin I Concentrations and Cardiovascular Events in the General Population: The HUNT Study (Nord-Trøndelag Health Study)
Main finding · cTnI concentrationResult — go to the resultB −0.098 95% CI −0.129 to −0.068Authors' conclusion
Current smoking is associated with lower concentrations of cTnI, suggesting that substances in tobacco smoke may affect cardiomyocyte injury. The association between cTnI levels and cardiovascular end points is stronger in never/former smokers than in current smokers, compatible with the theory that the detrimental cardiovascular impact of current smoking is mediated via mechanisms other than subclinical myocardial injury.
Study context
- Population
- HUNT Study participants free from known prior CVD and DM at baseline, aged 19–94 years, 55.5% women
- Participants
- 3,824 / 2,341 / 2,550
- Exposure
- Current smokers vs never and former smokers
- Never smokersn = 3,824reference
- Former smokersn = 2,341
- Current smokersn = 2,550
- Outcome
- High-sensitivity cTnI concentrations by smoking status, and association of cTnI with acute MI, HF and CV death
Methodological detailspopulation-based
- Population-based
Main finding
cTnI concentration
B
−0.098
95% CI −0.129 to −0.068
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Association of cardiac troponin I (cTnI) with clinical end points (AMI, HF, CV death), total study cohort
| Comparison | Adjusted HR per log unit increase in cTnI (95% CI) | |
|---|---|---|
| Total study cohort | 1.41 (1.29–1.54) | |
| 0.512Adjusted HR per log unit increase in cTnI (log scale) |
| Outcome | HR (95% CI) | |
|---|---|---|
| Association of cTnI with clinical end points, current smokersCurrent smokers vs Never smokers · significantly weaker than in never/former smokers | 1.17 (0.98–1.40) | |
| 0.512Hazard ratio (log scale) |
- Association of cTnI with clinical end points, current smokers: P for interaction=0.003
Prognostic accuracy (C statistics)
- Significantly lower in current smokers than in never smokers
- P < 0.001
Incremental prognostic information of cTnI to Framingham CVD risk score, current smokers
- No incremental prognostic information in current smokers
- P = 0.08
Original publication
Summarised from the published abstract; every number is checked against it