HypertensionRandomised controlled trial
Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial
- Randomised controlled trial
- three-arm
Authors' conclusion
Increasing STST improved blood pressure in overweight and obese postmenopausal women within 3 months.
Study context
- Population
- Overweight or obese sedentary postmenopausal women388 (95%) completed
- Participants
- 407 participants
- Comparison
- Reduce sitting time or increase sit-to-stand transitions vs healthy living
- Primary endpoint
- Behavioural and physiological impacts of changing sedentary behaviours (sitting time, STSTs, BP, glucoregulatory outcomes)
- Follow-up
- 3 months
Primary result
As reported in the abstract
Sitting time and STSTs (activPAL/ActiGraph accelerometers)
Each group vs healthy livingDifference, STST/day (95% CI)P value
Sit lessSTSTs
−1(−9.4 to 6.5)
P = 0.72Each group vs healthy livingDifference, STST per day (95% CI)P value
Sit-to-standincrease in STSTs
26(17.71–33.64)
P < 0.001Each group vs healthy livingDifference, min/day (95% CI)P value
Sit-to-standsitting time
−10(−34.6 to 14.9)
P = 0.44- Sit less · reduction in total sitting time
- difference 58 minutes per day (95% CI −82.9 to −33.6); P < 0.001
Further findings
| Outcome | difference (mm Hg) (95% CI) | P value | |
|---|---|---|---|
| BP · 3 months — Sit-to-stand vs Healthy living · DBP | −2.24 (−4.08 to −0.40) | P = 0.02 | |
| BP · 3 months — Sit-to-stand vs Healthy living | −3.33 (−6.32 to −0.33) | P = 0.03 | |
| −10−505Difference, mm Hg (linear scale) |
- BP: SBP; did not reach a priori significance threshold of P<0.025
- BP: a priori significance threshold P<0.025
BP · 3 months
- No significant intervention effects on BP for Sit less
Glucoregulatory outcomes · 3 months
- No intervention effects for either arm
Original publication
Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial. Circulation. Published 25 July 2025. doi:10.1161/circulationaha.124.073385
Summarised from the published abstract; every number is checked against it