Cardiometabolic & kidneyCohort study
Impaired Renal Function and Major Cardiovascular Events in Young Adults
- Retrospective cohort study
- linked provincial health care data sets, Ontario, Canada
Authors' conclusion
In young adults, eGFR below age-expected values were associated with an elevated risk for MACE and MACE+
Study context
- Population
- Adults aged 18–65 years, Ontario, Canada, January 2008-March 20213.6 million aged 18–39 years
- Participants
- 8.7 million adults
- Exposure
- Categorized eGFR, stratified by age
- Outcome
- MACE (first of cardiovascular (CV) mortality, ACS and ischemic stroke) and MACE+ (MACE plus HF)
- Follow-up
- Median 9.2 years
Main finding
As reported in the abstract
MACE at eGFR 70-79 mL/min/1.73 m², by age
eGFR 70-79Hazard ratio (95% CI)
ages 18-30 years: 2.37 events per 1,000 person years
1.31(1.27–1.40)
ages 40-49 years: 6.26 events per 1,000 person years
1.09(1.06–1.12)
ages 50-65 years: 14.9 events per 1,000 person years
1.07(1.05–1.08)
Per 1,000 person years, as printed
Observational data: associations, not effects.
Further findings
Each MACE component; additional analyses (past CVD, albuminuria at index, repeated eGFR)
- Results persisted
Original publication
Impaired Renal Function and Major Cardiovascular Events in Young Adults. J Am Coll Cardiol. Published 26 September 2023. doi:10.1016/j.jacc.2023.07.012
Summarised from the published abstract; every number is checked against it