Arrhythmias & electrophysiologyCohort study
Implantable cardioverter defibrillator therapy in paediatric patients for primary vs. secondary prevention
- Retrospective cohort study
- nationwide
- Danish ICD registry
- Median follow-up 9.0 (IQR 4.7-13.5) years
Authors' conclusion
In children, two-thirds are secondary prevention ICDs. Children have higher appropriate therapy and complication rates than adults, while the inappropriate therapy rate was low.
Study context
- Population
- Paediatric patients with ICD implanted at age ≤ 15, Denmark, 1982–21
- Participants
- 72 patients
- Exposure
- Primary vs secondary prevention ICD
- Primary preventionn = 23
- Secondary preventionn = 49reference
- Outcome
- Appropriate therapy (shock or anti-tachycardia pacing for VT or VF)
Main finding
As reported in the abstract
Appropriate therapy · 10 years
10-year cumulative incidence of first appropriate therapy (all patients)
70%
Observational data: associations, not effects.
Further findings
Age at implantation
P-value 0.01
Safety
Complications and inappropriate therapy · 10 years
- Complication rate
- 41%
- Inappropriate therapy rate
- 15%
- Deaths during follow-up
- 6
- No difference between prevention groups
Original publication
Implantable cardioverter defibrillator therapy in paediatric patients for primary vs. secondary prevention. Europace. Published 30 September 2024. doi:10.1093/europace/euae245
Summarised from the published abstract; every number is checked against it