Heart failure & cardiomyopathiesDiagnostic or prognostic study
Improved Diagnostic Criteria for Apical Hypertrophic Cardiomyopathy
- Diagnostic accuracy study
Authors' conclusion
Per-segment indexed apical wall thickness thresholds are highly accurate for detecting apical hypertrophy, providing confidence to the reader to diagnose ApHCM in those not reaching current internationally recognized criteria.
Study context
- Population
- Healthy subjects and clinically defined apical hypertrophic cardiomyopathy (ApHCM) patients; CMR-derived maximum wall thickness (MWT) by machine learning104 ApHCM
- Participants
- 72 / 32 / 4,112 / 489
- Comparison
- Indexed apical wall thickness threshold in ApHCM vs healthy subjects
- Overt ApHCMn = 72
- Relative ApHCMn = 32
- UK Biobankn = 4,112reference
- Healthy volunteersn = 489reference
- Outcome
- Normal apical wall thickness thresholds (indexed) and diagnostic performance for ApHCM
Performance
As reported in the abstract
Abnormal by indexed apical MWT threshold (upper limit of normal 5.2 to 5.6 mm/m²; accuracy 0.94; unindexed 11 mm)
- Upper limit of normal of maximum apical MWT
- 5.2 to 5.6 mm/m²
- Accuracy
- 0.94
Further findings
Determinants of apical wall thickness in healthy cohorts
- No clinically significant age-related difference; sex differences not clinically significant after indexing to BSA; indexing to BSA only required
Original publication
Improved Diagnostic Criteria for Apical Hypertrophic Cardiomyopathy. JACC Cardiovasc Imaging. Published 11 October 2023. doi:10.1016/j.jcmg.2023.07.012
Summarised from the published abstract; every number is checked against it