Acute cardiac care & resuscitation
Improved Mortality and Haemodynamics with Milrinone in Cardiogenic Shock Due to Acute Decompensated Heart Failure
Authors' conclusion
The use of milrinone compared with dobutamine in patients with ADHF-CS is associated with lower 30 day mortality and improved haemodynamics.
Study context
- Population
- Patients with cardiogenic shock due to acute decompensated HF (ADHF-CS), 2014–2020, treated with a single inodilator
- Participants
- 573 patients
- Exposure
- Milrinone vs dobutamine
- Milrinonen = 366
- Dobutaminen = 207reference
- Outcome
- Mortality, censored at transplant or LV assist device implantation
- Follow-up
- 30 days
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
Milrinone vs DobutamineHazard ratio (95% CI)
Adjusted
0.52(0.35–0.77)
After propensity-matching
0.51(0.27–0.96)
Observational data: associations, not effects.
Further findings
Haemodynamics
- Improved pulmonary artery compliance, stroke volume and RV stroke work index with milrinone
Original publication
Improved Mortality and Haemodynamics with Milrinone in Cardiogenic Shock Due to Acute Decompensated Heart Failure. ESC Heart Fail. Published 15 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →