Cohort study
Improved Outcomes After Pulmonary Valve Replacement in Repaired Tetralogy of Fallot
- Retrospective cohort study
- propensity-score matched
- multicentre registry
Authors' conclusion
Compared with rTOF patients who did not receive PVR, propensity score-matched individuals receiving PVR had lower risk of a composite endpoint of death or sustained VT.
Study context
- Population
- Patients with repaired tetralogy of Fallot (rTOF) in the INDICATOR registrymatched cohort n = 524
- Participants
- 1,143 patients
- Exposure
- Pulmonary valve replacement (PVR) vs no PVR
- Outcome
- Time to earliest occurrence of death or sustained VT
Main finding
Death or sustained VT
Adjusted hazard ratio
0.41
95% CI 0.21–0.81
P = 0.010
PVR vs No-PVR
adjusted HR 0.41 (95% CI 0.21–0.81); P = 0.010
As reported in the abstract
- Primary outcome events, whole cohort
- 82
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Death or sustained VT, by RV end-systolic volume index (subgroup) — PVR vs No-PVR · RV end-systolic volume index >80 mL/m² | 0.32 (0.16–0.62) | P < 0.001 | |
| Death or sustained VT, by RV end-systolic volume index (subgroup) — PVR vs No-PVR · RV end-systolic volume index ≤80 mL/m² | 0.86 (0.38–1.92) | P = 0.70 | |
| 0.10.31310Hazard ratio (log scale) |
- Death or sustained ventricular tachycardia (VT), by right ventricular (RV) end-systolic volume index (subgroup): interaction P = 0.046; full cohort
Original publication
Improved Outcomes After Pulmonary Valve Replacement in Repaired Tetralogy of Fallot. J Am Coll Cardiol. Published 30 May 2023. doi:10.1016/j.jacc.2023.02.052
Summarised from the published abstract; every number is checked against it