Arrhythmias & electrophysiologyCohort study
Improved outcomes with leadless vs. single-chamber transvenous pacemaker in haemodialysis patients
- Retrospective cohort study
- propensity-score matched
- French national REIN registry matched to national health databases (SNDS)
Authors' conclusion
With the limitations of its observational design, this study suggests that leadless pacemakers are associated with a lower rate of complications and better survival as compared with transvenous VVI pacemakers in haemodialysis patients
Study context
- Population
- Adult haemodialysis patients receiving a first single-chamber pacemaker, January 2017–December 2020after propensity matching
- Participants
- 178 patients
- Exposure
- Single-chamber leadless vs single-chamber transvenous pacemaker
- Leadlessn = 89
- Transvenousn = 89reference
- Outcome
- Survival (all-cause mortality) and related complications
- Follow-up
- Median 24 (range 7-37) months
Main finding
All-cause mortality
Hazard ratio
0.68
95% CI 0.47–0.99
Leadless vs Transvenous
HR 0.68 (95% CI 0.47–0.99)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Device-related infections · throughout follow-up | HR 0.43 (95% CI 0.21–0.86) | |
| Vascular access interventions on arteriovenous fistula | OR 0.53 (95% CI 0.33–0.68) | |
| 0.20.5125Ratio (log scale) |
Original publication
Improved outcomes with leadless vs. single-chamber transvenous pacemaker in haemodialysis patients. Europace. Published 1 October 2024. doi:10.1093/europace/euae257
Summarised from the published abstract; every number is checked against it