Prevention & lipidsCohort study
Improvements in walking speed reduce mortality in patients with cardiovascular disease during exercise-based secondary prevention: findings from the ITER registry
- Registry-based cohort study
Authors' conclusion
The 1k-TWT is an effective predictor of mortality among CVD patients and a valuable educational tool for exercise-based interventions in secondary prevention.
Study context
- Population
- Patients with stable cardiovascular disease (CVD) in exercise-based secondary prevention, ITER registry, 1997–20232,858 analysed
- Participants
- 3,328 patients
- Exposure
- Walking speed and mortality
- Outcome
- All-cause and disease-specific mortality by WS (1-km treadmill walking test)
- Follow-up
- Median 11 years
Main finding
As reported in the abstract
Mortality by baseline WS and WS change
Deaths
1031
Higher baseline walking speed (WS): lower cancer mortality risk
23% (95% CI 0.56, 1.06)
Higher baseline WS: lower CVD mortality risk
58% (95% CI 0.32, 0.54)
LowWS-improved: lower all-cause mortality risk (95% CI 0.52, 0.74), comparable to HighWS-decreased
38%
Observational data: associations, not effects.
Original publication
Improvements in walking speed reduce mortality in patients with cardiovascular disease during exercise-based secondary prevention: findings from the ITER registry. Eur J Prev Cardiol. Published 12 June 2025. doi:10.1093/eurjpc/zwaf347
Summarised from the published abstract; every number is checked against it