Pulmonary vascular disease & thromboembolismCohort study
Improving Balloon Pulmonary Angioplasty Through Target Endpoint Optimization With Pressure Catheter and Angiographic Lung Perfusion
- Prospective cohort study
- single-centre
Authors' conclusion
Functional assessment-guided PA dilation with a target pressure ratio of 0.7 proved beneficial in BPA treatment for patients with CTEPH. This approach improved the residual PH and reduced complications
Study context
- Population
- Patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing balloon pulmonary angioplasty (BPA)278 BPA sessions
- Participants
- 95 patients
- Exposure
- Pressure-guided vs angiographic BPA
- Pressure-guidedn = 28
- Angiographicn = 63reference
- Outcome
- Residual pulmonary hypertension (mean pulmonary artery pressure <25 mm Hg) and complications
Main finding
As reported in the abstract
Mean pulmonary artery pressure <25 mm Hg
P = 0.001
Observational data: associations, not effects.
Further findings
Target pressure ratio (141 pulmonary artery (PA) lesions)
- Target pressure ratio associated with significant enhancement in lung perfusion (piecewise linear regression)
- 0.7
Safety
BPA-relevant complications (per session) · 4/101 vs 23/177 sessions
P = 0.019
Original publication
Improving Balloon Pulmonary Angioplasty Through Target Endpoint Optimization With Pressure Catheter and Angiographic Lung Perfusion. JACC Cardiovasc Interv. Published 28 October 2024. doi:10.1016/j.jcin.2024.08.045
Summarised from the published abstract; every number is checked against it