Arrhythmias & electrophysiologyRandomised controlled trial
Improving outcomes of atrial fibrillation ablation by integrated personalized lifestyle interventions: a randomized controlled trial
- Randomised controlled trial
- prospective
Authors' conclusion
Integrated lifestyle modification before catheter ablation reduces both repeat ablations and direct current cardioversions by half until 12 months after index ablation.
Study context
- Population
- Patients referred for their first atrial fibrillation (AF) ablation
- Participants
- 145 patients
- Comparison
- Integrated lifestyle treatment (ILT) vs Control
- ILTn = 75
- Controln = 70reference
- Primary endpoint
- Composite of:
- Hospitalizations for repeat ablations
- Direct current cardioversions (event-rate analysis)
- Follow-up
- Up to 12 months after pulsed-field PVI
Primary result
As reported in the abstract
Incidence relative risk
0.49
95% CI 0.30–0.78
P = 0.004
Events by treatment group
Control
492/1000 patient-years
52 of 70
ILT
240/1000 patient-years
25 of 75
ILT vs Control
incidence RR 0.49 (95% CI 0.30–0.78); P = 0.004
Further findings
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Repeat ablations | 0.43 (0.18–0.94) | P = 0.045 | |
| Direct current cardioversions | 0.52 (0.28–0.92) | P = 0.031 | |
| 0.20.5125Relative risk (log scale) |
Original publication
Improving outcomes of atrial fibrillation ablation by integrated personalized lifestyle interventions: a randomized controlled trial. Eur Heart J. Published 30 August 2025. doi:10.1093/eurheartj/ehaf689
Summarised from the published abstract; every number is checked against it