Coronary disease & ACSCohort study
In-hospital cardiac arrest in non-ST-segment elevation myocardial infarction: characteristics and association of early intervention with risk-findings from the CCC-ACS project
- retrospective cohort study
- nationwide
Authors' conclusion
IHCA remains a fatal complication of NSTEMI, often occurring early after admission. Recognition of high-risk features, timely initiation of coronary angiography, and implementation of guideline-directed therapies may reduce IHCA occurrence.
Study context
- Population
- Patients diagnosed with NSTEMI between November 2014 and December 2020 in the CCC-ACS project in ChinaNSTEMI patients (29.45% female, mean age, 65.25 years), 397 (1.24%) developed in-hospital cardiac arrest (IHCA)
- Participants
- 32,094 patients
- Exposure
- stratified by IHCA occurrence
- IHCAn = 397
Main finding
As reported in the abstract
IHCA incidence
IHCA incidence among NSTEMI patients
397 (1.24%)
IHCA incidence in 2014
2.06%
IHCA incidence in 2020
0.89%
Observational data: associations, not effects.
Further findings
- In-hospital mortality of IHCA patients
- 65.74%
Timing of IHCA
- IHCA on the day of admission
- 25.59%
- median time to IHCA, days
- 4 [1-7]
Risk and protective factors for IHCA (Cox proportional hazards models)
- Risk factors: prior out-of-hospital cardiac arrest, ≥100-fold elevated TnT/TnI levels, age ≥75 years, Killip class IV, systolic blood pressure <90 mmHg, and heart rate >100 bpm at admission, history of heart failure, renal failure, ischemic stroke, and the latest glucose level >10 mmol/L
- Coronary angiography before IHCA was the strongest protective factor
Original publication
In-hospital cardiac arrest in non-ST-segment elevation myocardial infarction: characteristics and association of early intervention with risk-findings from the CCC-ACS project. Resuscitation. Published 17 March 2026. doi:10.1016/j.resuscitation.2026.111064
Summarised from the published abstract; every number is checked against it