Arrhythmias & electrophysiologyCohort study
In-hospital safety outcomes of left atrial appendage occlusion in octogenarians and nonagenarians
- Retrospective cohort study
- National Inpatient Sample database
Authors' conclusion
Octogenarians and nonagenarians undergoing LAAO have a similar safety profile compared with clinically similar younger patients except for higher odds of vascular complications.
Study context
- Population
- Patients hospitalized for Left Atrial Appendage Occlusion (LAAO), US National Inpatient Sample, 2016–2020
- Participants
- 84,140 patients
- Exposure
- Octogenarians and nonagenarians vs younger patients undergoing LAAO
- Outcome
- Composite of:
- In-hospital all-cause mortality
- Stroke
- Follow-up
- In-hospital
Main finding
As reported in the abstract
In-hospital all-cause mortality or stroke
Each group vs youngerAdjusted odds ratio (95% CI)
Octogenarians
1.41(0.93–2.13)
Nonagenarians
1.69(0.67–3.92)
Observational data: associations, not effects.
Secondary outcomes
Age distribution of LAAO patients
LAAO volume over the study period
- Volume increased in all age groups
- all Ptrend < 0.01
Length of stay (LOS) and total costs
- Similar LOS and total costs vs younger patients
- all P > 0.05
Safety
| Outcome | aOR (95% CI) | |
|---|---|---|
| Vascular complications · in-hospital — Octogenarians vs Younger | 1.47 (1.08–1.99) | |
| Vascular complications · in-hospital — Nonagenarians vs Younger | 1.60 (1.18–2.97) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Cardiac tamponade, AKI, major bleeding, blood transfusion · in-hospital
- Similar odds in octogenarians and nonagenarians vs younger patients
- all P > 0.05
Original publication
In-hospital safety outcomes of left atrial appendage occlusion in octogenarians and nonagenarians. Europace. Published 23 February 2024. doi:10.1093/europace/euae055
Summarised from the published abstract; every number is checked against it