Cohort study
In Vivo Coronary 18F-Sodium Fluoride Activity
- Prospective cohort study
Authors' conclusion
Coronary 18F-NaF activity was associated with histological vulnerability, CD68 expression, inflammatory cytokines expression, but not with osteogenic differentiation cytokines expression.
Study context
- Population
- Patients with coronary artery disease (CAD) undergoing CABG with adjunctive coronary endarterectomy, with coronary computed tomography angiography (CTA) and 18F-NaF positron emission tomography (PET)/computed tomography (CT)55 specimens
- Participants
- 42 patients
- Exposure
- High-risk vs low- to medium-risk plaques
- Outcome
- Association of in vivo coronary 18F-NaF PET/CT activity with ex vivo histological plaque vulnerability
Main finding
As reported in the abstract
Coronary 18F-NaF activity
High-risk
1.88
median · IQR 1.41–2.54
Low- to medium-risk
1.12
median · IQR 0.91–1.54
P < 0.001
Observational data: associations, not effects.
Further findings
Discrimination of high-risk plaque by coronary 18F-NaF activity
- AUC
- 0.80
Correlates of coronary 18F-NaF activity
- CTA adverse plaque features (positive remodeling, low-attenuation plaque, remodeling index), histologically vulnerable features (large necrotic core, thin fibrous cap, microcalcification), CD68, TNF-α and IL-1β expression correlated with 18F-NaF activity
- all P < 0.05
- No significant association with osteogenic differentiation cytokines
- all P > 0.05
Original publication
In Vivo Coronary 18F-Sodium Fluoride Activity. JACC Cardiovasc Imaging. Published 11 May 2022. doi:10.1016/j.jcmg.2022.03.018
Summarised from the published abstract; every number is checked against it