Arrhythmias & electrophysiologyCohort study
Incidence and predictors of 2-year mortality following percutaneous left atrial appendage occlusion in the EWOLUTION trial
- Prospective registry cohort study (analysis of the EWOLUTION registry)
- real-world registry
- pre-specified endpoint definitions
Authors' conclusion
One in six patients died within 2 years after LAAO. We identified six independent predictors of mortality. When combined, this model showed a gradual increase in mortality rate with a growing number of risk factors
Study context
- Population
- Patients who underwent percutaneous left atrial appendage occlusion (LAAO) in the EWOLUTION registry
- Participants
- 1,020 patients
- Outcome
- All-cause mortality and its baseline predictors
- Follow-up
- 2 years
Main finding
As reported in the abstract
2-year mortality
- 2-year mortality rate (Kaplan-Meier); CI 14.0-18.7%
- 16.4%
- Deaths from a non-CV cause
- 50%
- Predictor: age, per year increase
- 1.05 (HR; CI 1.03-1.08)
- Predictor: HF
- 1.73 (HR; CI 1.24-2.41)
- Predictor: vascular disease
- 1.47 (HR; CI 1.05-2.05)
- Predictor: valvular disease
- 1.63 (HR; CI 1.15-2.33)
- Predictor: abnormal liver function
- 1.80 (HR; CI 1.02-3.17)
- Predictor: abnormal renal function
- 1.58 (HR; CI 1.10-2.27)
- Mortality with five or six risk factors
- 46.1%
Observational data: associations, not effects.
Original publication
Incidence and predictors of 2-year mortality following percutaneous left atrial appendage occlusion in the EWOLUTION trial. Europace. Published 31 July 2024. doi:10.1093/europace/euae188
Summarised from the published abstract; every number is checked against it