Arrhythmias & electrophysiologyMeta-analysis
Incidence and predictors of major arrhythmic events after acute myocarditis complicated by ventricular arrhythmias: A systematic review and meta-analysis
- systematic review and meta-analysis
- random-effects models
- registered in PROSPERO
Authors' conclusion
MAE recurrences after AM affect nearly half of patients with sustained VA during the acute phase. No consistent predictors emerged. These findings are consistent with the European Society of Cardiology guidelines and call for refined risk stratification from large, multicenter cohorts with standardized criteria.
Study context
- Population
- Patients with acute myocarditis (AM) complicated by sustained ventricular arrhythmias (VAs) in the acute phase
- Participants
- 355 patients · 8 observational studies
- Outcome
- MAE (documented sustained VA, appropriate ICD therapy, or sudden cardiac death)
- Follow-up
- Mean pooled 3.8 years (95% confidence interval, 2.7-5.1)
Pooled result
As reported in the abstract
MAE occurred (pooled rate)
46.4% (95% confidence interval, 38.1-54.9; I2 = 50.0)
Further pooled results
Predictors of MAE: demographic factors (age and sex), comorbidities, cardiovascular risk factors, implantable cardioverter-defibrillator (ICD) implantation before discharge
- Not associated with MAE at follow-up
Predictors of MAE: reduced left ventricular ejection fraction, presence or localization of late gadolinium enhancement on cardiac magnetic resonance
- Not predictive
Original publication
Summarised from the published abstract; every number is checked against it