Valvular & structural heart diseaseCohort study
Incidence and Prognosis of Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement for Bicuspid Aortic Stenosis
- Registry-based cohort study
- prospective registry
- multicentre
- propensity-score matched
Authors' conclusion
Severe PPM appeared to be associated with all-cause mortality. Moderate and severe PPM were more frequently observed in patients with tricuspid AS than patients with bicuspid AS.
Study context
- Population
- Patients undergoing transcatheter aortic valve replacement (TAVR) in the Japanese multicentre OCEAN-TAVI registry7,393 enrolled
- Participants
- 7,051 patients
- Exposure
- Bicuspid AS vs tricuspid AS after TAVR
- Bicuspid ASn = 497
- Tricuspid ASn = 497reference
- Outcome
- Incidence of PPM and long-term mortality
Main finding
As reported in the abstract
Moderate and severe PPM (matched cohort)
Moderate PPM
Severe PPM
- Tricuspid AS vs Bicuspid AS: P = 0.0001
Observational data: associations, not effects.
Further findings
Prosthesis-patient mismatch (PPM) incidence, overall cohort
- Moderate PPM
- 756 (10.7%)
- Severe PPM
- 92 (1.3%)
Long-term mortality with severe PPM, overall cohort
- Severe PPM appeared to be associated with long-term mortality (log-rank test)
- P = 0.065
Original publication
Incidence and Prognosis of Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement for Bicuspid Aortic Stenosis. JACC Cardiovasc Interv. Published 8 January 2025. doi:10.1016/j.jcin.2024.10.002
Summarised from the published abstract; every number is checked against it