Arrhythmias & electrophysiologyMeta-analysis
Incidence and type of recurrent ventricular arrhythmia in patients with arrhythmic mitral valve prolapse and implantable cardioverter defibrillator for secondary prevention
- Systematic review and meta-analysis
Authors' conclusion
Arrhythmic MVP patients with ICDs for secondary prevention exhibit a high risk of recurrent arrhythmias, with recurrences in the form of polymorphic VA occurring in more than half of the cases.
Study context
- Population
- Arrhythmic mitral valve prolapse (MVP) patients with an implantable cardioverter-defibrillator (ICD) implanted for secondary prevention
- Participants
- 166 patients · 9 studies
- Outcome
- Incidence of appropriate ICD therapies and type of arrhythmia recurrence
Pooled result
As reported in the abstract
weighted mean follow-up 4.9 ± 3.1 years
Recurrence of VA
34.9% (95% CI 28.1-42.5)
Pooled incidence of appropriate ICD therapies
8.1 per 100 person-years (95% CI 5.6-10.5, I2: 11.7%)
Recurrences as VF or polymorphic ventricular tachycardia (VT) (remainder monomorphic VT)
53.8% (95% CI 44.3-63.0%)
Further pooled results
Shock therapy among VA episodes
- 65 of 67 episodes required shock (7 studies)
- 97.0% (95% CI 89.6-99.6%)
Original publication
Incidence and type of recurrent ventricular arrhythmia in patients with arrhythmic mitral valve prolapse and implantable cardioverter defibrillator for secondary prevention. Europace. Published 15 May 2026. doi:10.1093/europace/euag101
Summarised from the published abstract; every number is checked against it