Valvular & structural heart diseaseCohort study
Incidence, Clinical Implications, and Predictors of Paravalvular Leak Following Transcatheter Tricuspid Valve Replacement
- Multicentre registry study
- multicenter
Authors' conclusion
Moderate or greater PVL occurred in 6.1% of patients post-TTVR and was associated with increased 1-year mortality and worse functional status.
Study context
- Population
- Patients undergoing transcatheter tricuspid valve replacement (TTVR) in the multicenter TRIPLACE registry, stratified by predischarge paravalvular leak (PVL) severity
- Participants
- 394 patients
- Exposure
- Moderate or severe vs mild vs no or trace PVL post-TTVR
- Moderate or severe PVLn = 24
- Mild PVLn = 88
- No or trace PVLn = 282reference
- Outcome
- Moderate or severe PVL post-TTVR
- Follow-up
- Predischarge
Main finding
As reported in the abstract
PVL severity post-TTVR
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Moderate or severe PVL | Mild PVL | No or trace PVL | adjusted HR (95% CI) | |
|---|---|---|---|---|---|
| 1-year mortality · vs mild or no/trace PVL | 39.7% | 12.6% | 10.5% | 2.6 (1.2–5.7) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
NYHA class III or IV · 1 month
Independent predictors of moderate or severe PVL
- Larger right atrial volume
- P = 0.02
- Device malposition
- P = 0.0002
- Type IV valve morphology
- P = 0.01
Original publication
Incidence, Clinical Implications, and Predictors of Paravalvular Leak Following Transcatheter Tricuspid Valve Replacement. JACC Cardiovasc Interv. Published 23 March 2026. doi:10.1016/j.jcin.2026.01.281
Summarised from the published abstract; every number is checked against it