Acute cardiac care & resuscitation
Incidence of hypoxic hepatitis in patients with cardiogenic shock and association with mortality
Main findingResult — go to the resultOdds ratio 2.36 95% CI 1.61–3.49Authors' conclusion
The C-HH is a frequent and relevant comorbidity in patients with CS, although its definition varies from the established definition of HH in patients with septic shock.
Study context
- Population
- All-comer adult patients with cardiogenic shock treated 2009–2019 at a tertiary care centre
- Participants
- 698 patients
- Exposure
- C-HH vs no C-HH
- C-HHn = 254
- Outcome
- Incidence of hypoxic hepatitis in CS (C-HH) and its association with in-hospital mortality
- Follow-up
- In-hospital
Methodological detailssingle-centre, tertiary care centre
- Single-centre
- Tertiary care centre
Main finding
As reported in the abstract
Odds ratio
2.36
95% CI 1.61–3.49
Events by group
C-HH
36%
254
C-HHvs No C-HH
OR 2.36 (95% CI 1.61–3.49)
Observational data: associations, not effects.
Further findings
In-hospital mortality, overall
- Patients who died during in-hospital follow-up
- 386 (55.3%)
Septic-shock HH definition (shock, hypoxic hepatitis (S-HH); 20-fold ULN of aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT)) and in-hospital mortality
- S-HH not significantly associated with in-hospital mortality in cardiogenic shock (CS)
Original publication
Incidence of hypoxic hepatitis in patients with cardiogenic shock and association with mortality. Eur Heart J Acute Cardiovasc Care. Published 6 July 2023. doi:10.
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