Valvular & structural heart diseaseCohort study
Incidence, Predictors, and Management of Conduction Disturbances After Transcatheter Tricuspid Valve Replacement
- Multicentre registry cohort study
- consecutive patients
Authors' conclusion
HAVB occurred in 13.5% of PPI-naive patients who underwent TTVR. The majority of cases of HAVB (88%) were observed in the first week after TTVR. Baseline left bundle branch block or left anterior or posterior fascicular block confers a high risk for HAVB after TTVR.
Study context
- Population
- Patients undergoing transcatheter tricuspid valve replacement (TTVR) in the TRIPLACE registry185 permanent pacemaker implantation (PPI)-naive analysed
- Participants
- 263 patients
- Outcome
- High-grade atrioventricular block (HAVB)
- Follow-up
- 1 month post-TTVR
Main finding
As reported in the abstract
HAVB · 1 month
HAVB in PPI-naive patients (25 of 185)
13.5%
HAVB within first week post-TTVR
88%
Time to HAVB, median (Q1-Q3 2.0-5.0)
3.0 days
Observational data: associations, not effects.
Further findings
Predictor of HAVB
| Comparison | adjusted OR (95% CI) | P value | |
|---|---|---|---|
| Baseline left bundle branch block or left anterior or posterior fascicular block · adjusted for age and degree of device oversizing | 3.63 (1.28–10.37) | P = 0.016 | |
| 0.050.21520Adjusted odds ratio (log scale) |
Timing of HAVB
- HAVB within the first week post-TTVR
- 88%
- Median time to HAVB (Q1-Q3: 2.0-5.0)
- 3.0 days
New-onset right bundle branch block
- New-onset right bundle branch block
- 20.6%
PPI technique
- Leadless technologies
- 45.5%
- Coronary sinus leads
- 27.3%
- Transvalvular dual-chamber pacemakers
- 27.3%
Original publication
Incidence, Predictors, and Management of Conduction Disturbances After Transcatheter Tricuspid Valve Replacement. JACC Cardiovasc Interv. Published 9 July 2025. doi:10.1016/j.jcin.2025.05.029
Summarised from the published abstract; every number is checked against it