Valvular & structural heart diseaseCohort study
Incidence, Predictors and Outcomes of Bleeding Following Transcatheter Tricuspid Valve Repair
- Retrospective analysis of an international multicentre registry
Authors' conclusion
BARC major bleeding occurs in about 11% of patients following transcatheter tricuspid valve repair and is a major determinant of in-hospital and 1-year death.
Study context
- Population
- Patients undergoing transcatheter tricuspid valve repair (TriValve registry)
- Participants
- 440 patients
- Exposure
- Major bleeding vs no major bleeding
- Outcome
- BARC bleeding (types 2, 3 and 5), its predictors and prognostic implications
- Follow-up
- Within 1 year
Main finding
As reported in the abstract
BARC major bleeding incidence
Bleeding Academic Research Consortium (BARC) major bleeding incidence (50 patients)
11.4%
Observational data: associations, not effects.
Further findings
Predictors of BARC major bleeding · within 1 year
| Comparison | adjusted OR (95% CI) | P value | |
|---|---|---|---|
| Postprocedural tricuspid regurgitation severity | 1.83 (1.12–3.01) | P = 0.02 | |
| Higher systolic pulmonary artery pressures | 1.61 (1.16–2.24) | P = 0.0048 | |
| Increasing procedure duration | 1.49 (1.00–2.22) | P = 0.049 | |
| Concomitant oral anticoagulation · not associated with bleeding | 1.51 (0.74–3.10) | P = 0.30 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Outcomes associated with bleeding
| Comparison | adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Bleeding · 1-year death or all-cause hospital readmission | 2.41 (1.39–4.19) | P = 0.002 | |
| Bleeding · all-cause death | 3.55 (1.75–7.21) | P = 0.0004 | |
| Bleeding · CV death | 3.72 (1.62–8.52) | P = 0.002 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
| Outcome | adjusted OR (95% CI) | P value |
|---|---|---|
| Outcomes associated with bleeding — Major bleeding · in-hospital death | 106 (1.31–8,553) | P = 0.04 |
Original publication
Incidence, Predictors and Outcomes of Bleeding Following Transcatheter Tricuspid Valve Repair. JACC Cardiovasc Interv. Published 23 March 2026. doi:10.1016/j.jcin.2026.01.288
Summarised from the published abstract; every number is checked against it