Valvular & structural heart diseaseCohort study
Incidence, Predictors, and Outcomes of Unplanned Coronary Angiography After Transcatheter Aortic Valve Replacement
- Retrospective cohort study
Authors' conclusion
Unplanned angiography post-TAVR occurs in about 1 in 15 patients, with about one-half occurring within the first year, about one-half due to acute coronary syndrome, and pre-existing CAD being the strongest predictor.
Study context
- Population
- Patients undergoing transcatheter aortic valve replacement (TAVR), July 2015–December 2021
- Participants
- 1,444 patients
- Exposure
- Preprocedural coronary artery disease (CAD) vs Others
- Outcome
- Incidence, predictors and outcomes of unplanned coronary angiography after TAVR
Main finding
As reported in the abstract
Unplanned post-TAVR angiography
P < 0.001
- Unplanned post-TAVR angiography, overall
- 6.7%
- Within the first year
- 45%
- Indication ACS, overall
- 3.3%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Factors associated with unplanned angiography (multivariable) — Age >75 years vs Others | 0.46 (0.30–0.71) | P < 0.001 | |
| Factors associated with unplanned angiography (multivariable) — Mean aortic valve gradient vs Others | 0.82 (0.68–0.98) | P = 0.031 | |
| Factors associated with unplanned angiography (multivariable) — Dialysis vs Others | 2.68 (1.07–6.74) | P = 0.036 | |
| Factors associated with unplanned angiography (multivariable) — CAD vs Others | 2.96 (1.76–4.98) | P < 0.001 | |
| 0.10.31310Hazard ratio (log scale) |
5-year prediction of unplanned angiography (multivariate models)
- AUC
- 0.71 to 0.77
Original publication
Incidence, Predictors, and Outcomes of Unplanned Coronary Angiography After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 23 October 2024. doi:10.1016/j.jcin.2024.07.042
Summarised from the published abstract; every number is checked against it