Incident cardiovascular events in women with left-sided versus right-sided breast cancer: a propensity score-matched study
Main finding · AFResult — go to the resultHazard ratio 1.051 95% CI 1.016–1.088Authors' conclusion
In this large international analysis, left-sided BC was significantly associated with a numerically marginal but statistically significant higher risk of AF than right-sided BC, while there were no differences for BC laterality regarding all-cause death and other cardiovascular events.
Study context
- Population
- Women with breast cancer, international TriNetX networkmatched cohort
- Exposure
- Left-sided vs right-sided breast cancer
- Outcome
- Mortality, AF, ventricular tachyarrhythmia, HF and ICD implantation
- Follow-up
- Maximum 8 years
Methodological detailspropensity-score matched (1:1), TriNetX global healthcare data
- Propensity-score matched (1:1)
- TriNetX global healthcare data
Main finding
AF · median follow-up 3.2 years
Hazard ratio
1.051
95% CI 1.016–1.088
P = 0.004
Left-sided BCvs Right-sided BC
HR 1.051 (95% CI 1.016–1.088); P = 0.004
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| AF, by RT (subgroup)Left-sided BCvs Right-sided BCNo RT | 1.045 (1.006–1.084) | P = 0.02 | |
| 0.512Hazard ratio (log scale) |
| Outcome | Estimate | P value |
|---|---|---|
| AF, by RT (subgroup)Left-sided BC vs Right-sided BC · treated with RT | 1.024 (95% CI 0.941–1.113) | P = 0.58 |
- Atrial fibrillation (AF), by radiotherapy (RT) (subgroup): p for interaction 0.66
Original publication
Incident cardiovascular events in women with left-sided versus right-sided breast cancer: a propensity score-matched study. Heart. Published 18 August 2025. doi:10.
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