Arrhythmias & electrophysiologySecondary analysis
Incident heart failure in patients with screening-detected atrial fibrillation: a post hoc analysis of the STROKESTOP and STROKESTOP II studies
- Post hoc analysis of the STROKESTOP and STROKESTOP II randomised screening studies
- registry-based outcomes
- Cox regression
Authors' conclusion
Screening-detected atrial fibrillation is associated with a high risk of heart failure, comparable to known atrial fibrillation, and is not a benign condition.
Study context
- Population
- Individuals aged 75–76 years without prior HF invited to ECG-based AF screening
- Comparison
- Screening-detected AF vs known AF vs no AF
- Primary endpoint
- Incident HF (national registries)
Primary result
As reported in the abstract
Screening-detected atrial fibrillation
23%
STROKESTOP: developed HF · STROKESTOP: incidence 3.76 per 100 person-years · STROKESTOP II: developed HF 20% · STROKESTOP II: incidence 4.19 per 100 person-years
Known atrial fibrillation
4.43 per 100 person-years
STROKESTOP: incidence · STROKESTOP II: incidence 3.52 per 100 person-years
No atrial fibrillation
1.08 per 100 person-years
STROKESTOP: incidence · STROKESTOP II: incidence 0.93 per 100 person-years
Adjusted HR
- STROKESTOP
- 3.19
- STROKESTOP II
- 4.73
- STROKESTOP: risk comparable to known AF (adjusted HR)
- 2.86
- STROKESTOP II: higher risk than known AF (adjusted HR)
- 2.59
Original publication
Summarised from the published abstract; every number is checked against it