Heart failure & cardiomyopathiesCohort study
Incident Heart Failure is Common and Underrecognized in Patients with Biopsy-Proven Metabolic Dysfunction-Associated Steatotic Liver Disease
- Prospective cohort study
- single-cohort
- biopsy-proven MASLD
Authors' conclusion
We found a high incidence of HF in patients with biopsy-proven MASLD. Despite nearly half of patients having suspected HF, very few carried a chart diagnosis.
Study context
- Population
- Patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease (MASLD), Duke NAFLD Biorepository, biopsy 2007–2013560 assessed for incident heart failure (HF)
- Participants
- 570 patients
- Outcome
- Incident HF (HF hospitalization, chart diagnosis, ≥1 sign/symptom with elevated natriuretic peptide, or diastolic dysfunction on echocardiography with ≥1 sign/symptom)
- Follow-up
- Median 4009 days (11.0 years)
Main finding
As reported in the abstract
Incident HF · median 11.0 years
Incident HF
100 (17.9%)
Met criteria for HF suspicion
268 (47.9%)
Increasing age associated with incident HF
multivariable OR 1.05 (95% CI 1.02-1.08, p < 0.001)
Female sex associated with incident HF
multivariable OR 1.85 (95% CI 1.12-3.04, p = 0.02)
Observational data: associations, not effects.
Further findings
Baseline HF
- Baseline HF
- 10 (1.8%)
Original publication
Incident Heart Failure is Common and Underrecognized in Patients with Biopsy-Proven Metabolic Dysfunction-Associated Steatotic Liver Disease. Eur J Heart Fail. Published 19 May 2025. doi:10.1002/ejhf.3697
Summarised from the published abstract; every number is checked against it