Cardio-oncology & otherCohort study
Incident Myocardial Infarction, Heart Failure, and Oncologic Outcomes in Breast Cancer Survivors
- Population-based cohort study
- landmark analysis
- time-varying exposure
- multivariable cause-specific hazards regression
Authors' conclusion
Incident MI and/or HF after breast cancer treatment are associated with higher hazards of adverse oncologic outcomes
Study context
- Population
- Women with first breast cancer (2007–2015), Ontario, Canada, alive 2 years after diagnosis, aged ≥40, without recurrent/distant disease or preceding cardiovascular disease (CVD)median age 60 years
- Participants
- 30,694 women
- Exposure
- Incident myocardial infarction (MI)/heart failure (HF) vs no incident MI/HF
- Incident MI/HFn = 1,346
- Outcome
- Cancer mortality, new non-breast malignancy, new chemotherapy initiation
Main finding
As reported in the abstract
Incident MI/HF vs No incident MI/HFHazard ratio (95% CI)
cancer death
3.94(3.38–4.59)
non-breast malignancy
1.39(1.06–1.82)
new chemotherapy
1.25(1.02–1.53)
Observational data: associations, not effects.
Further findings
Cumulative incidence, whole cohort · 5 years
- Cancer death
- 5.9% (95% CI: 5.6%-6.1%)
- Non-breast malignancy
- 4.3% (95% CI: 4.1%-4.6%)
- New chemotherapy
- 25.7% (95% CI: 25.2%-26.2%)
Original publication
Incident Myocardial Infarction, Heart Failure, and Oncologic Outcomes in Breast Cancer Survivors. JACC CardioOncol. Published 5 November 2024. doi:10.1016/j.jaccao.2024.08.008
Summarised from the published abstract; every number is checked against it