Increased Cardiac Risk After a Second Malignant Neoplasm Among Childhood Cancer Survivors: A FCCSS Study
Authors' conclusion
The occurrence of a SMN among CCS is associated with an increased risk of cardiac disease occurrence and risk at younger ages.
Study context
- Population
- Childhood cancer survivors, French Childhood Cancer Survivors Study cohort, diagnosed 1945–2000median follow-up 30 years
- Participants
- 7,670 survivors
- Exposure
- Second malignant neoplasm (SMN) vs no SMN
- Outcome
- Cardiac disease after a SMN
Methodological detailslandmark approach, time-dependent exposure, competing-risk analysis
- Landmark approach
- Time-dependent exposure
- Competing-risk analysis
Main finding
As reported in the abstract
Cardiac disease · median follow-up 30 years (IQR: 22-38 years)
SMN vs No SMNCumulative incidence difference (95% CI)
25-year landmark
3.8%(0.5%–7.1%)
SMN vs No SMNCause-specific hazard ratio (95% CI)
SMN as time-dependent exposure
2.0(1.4–2.8)
- Cases of cardiac disease
- 378
- Cases of cardiac disease with a SMN
- 49
Observational data: associations, not effects.
Original publication
Increased Cardiac Risk After a Second Malignant Neoplasm Among Childhood Cancer Survivors: A FCCSS Study. JACC CardioOncol. Published 3 October 2023. doi:10.
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