Increased Interleukin-6 is Associated with Higher Risk of Heart Failure in People with Type 2 Diabetes
Authors' conclusion
Higher IL-6 levels are associated with the development of HF in persons with T2D.
Study context
- Population
- Persons with T2DM in primary care (Diabetes Care System Cohort)141 heart failure (HF) cases · 583 controls
- Participants
- 724 persons
- Comparison
- IL-6 tertiles vs IL-6 below detection limit
- Outcome
- New-onset HF
- Follow-up
- 5 years
Methodological detailsage- and sex-matched
- Age- and sex-matched
Main finding
As reported in the abstract
Odds ratio (95% CI)
Tertile 1vs Group 1
2.1(1.2–2.9)
Tertile 2vs Group 1
2.8(2.0–3.7)
Tertile 3vs Group 1
2.1(1.3–3.0)
Continuous IL-6
1.2(1.0–1.5)
Observational data: associations, not effects.
Further findings
- No effect modification by sex
Original publication
Increased Interleukin-6 is Associated with Higher Risk of Heart Failure in People with Type 2 Diabetes. ESC Heart Fail. Published 28 March 2024. doi:10.
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