Heart failure & cardiomyopathies
Incremental value of multiparametric cardiac magnetic resonance imaging for non-invasive identification of significant acute cardiac allograft rejection: a prospective and biopsy-proven study
Authors' conclusion
LVGLS and T2 value were independently associated with SR, providing incremental value for non-invasive identification of significant rejection in HTx recipients.
Study context
- Population
- Heart transplantation (HTx) recipients with endomyocardial biopsy and healthy controls30 controls and 51 HTx recipients enrolled for analysis · controls 30 · HTx recipients 51
- Participants
- 23 / 28 / 30
- Exposure
- SRs compared with NSRs
- SRn = 23
- NSRn = 28
- Controln = 30
- Outcome
- NT-proBNP
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Independent association with SR (multivariable, NT-proBNP adjusted)LVGLS · per unit · after NT-proBNP adjustment | 0.76 (0.59–0.98) | P = 0.03 | |
| Independent association with SR (multivariable, NT-proBNP adjusted)T2 value · per unit · after NT-proBNP adjustment | 1.35 (1.10–1.65) | P = 0.01 | |
| 0.512Odds ratio (log scale) |
| Outcome | SR | NSR | P value |
|---|---|---|---|
| LV global longitudinal strain (GLS)SR vs NSR · worse in SR · mean, % | −9.7 (SD 3.1) | −13.1 (SD 2.9) | P < 0.001 |
| Native T1SR vs NSR · increased in SR · mean, ms | 1384 (SD 80.1) | 1321 (SD 69.9) | P < 0.001 |
| T2 valueSR vs NSR · increased in SR · mean, ms | 50.9 (SD 2.7) | 45.7 (SD 4.3) | P < 0.001 |
Incremental value over N-terminal pro-brain natriuretic peptide (NT-proBNP) for identifying SR (likelihood ratio test)
- LVGLS
- P = 0.002
- T2 value
- P < 0.001
Original publication
Incremental value of multiparametric cardiac magnetic resonance imaging for non-invasive identification of significant acute cardiac allograft rejection: a prospective and biopsy-proven study. Eur Heart J Cardiovasc Imaging. Published 11 February 2025. doi:10.
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