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Valvular & structural heart diseaseCohort study

Indexed Aortic Valve Calcium Volume by Computed Tomography Angiography in Patients With Aortic Stenosis

JACC Cardiovasc ImagingPublished

  • Retrospective cohort study
  • international
  • multicentre
  • observational
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Authors' conclusion

In patients with aortic stenosis, indexed aortic valve calcium volume from CTA provides accurate discrimination of disease severity and additive prognostic information.

Study context

Population
Patients with mild to severe AS with concurrent computed tomography angiography (CTA) and echocardiographyderivation 689, validation 459
Participants
1,521 patients
Exposure
Indexed aortic valve calcium volume by CTA for AS severity and prognosis

Main finding

As reported in the abstract

Diagnosis of severe AS (derivation cohort)
GroupC-statistic
Men0.900
Women0.926

Observational data: associations, not effects.

Further findings

AVR or all-cause mortality by indexed calcium volume thresholds

ComparisonHR (95% CI)P value
Indexed calcium volume thresholds · whole cohort; independently associated2.01 (1.30–3.10)P < 0.01
Indexed calcium volume thresholds · discordant echocardiography1.58 (1.01–2.44)
  • AVR or all-cause mortality by indexed calcium volume thresholds: outcomes available in 711 patients

Correlation of indexed AV calcium volume with peak aortic jet velocity and noncontrast computed tomography (CT) calcium score

Correlation with peak aortic jet velocity (ρ)
0.723; P < 0.001
Correlation with noncontrast CT calcium score (ρ)
0.896; P < 0.001

Diagnostic discrimination for severe AS by sex-specific indexed calcium volume thresholds (men: 122 mm3/cm²; women: 61 mm3/cm²)

C-statistic, men, derivation cohort (n = 689)
0.900
C-statistic, women, derivation cohort (n = 689)
0.926
C-statistic, men, validation cohort (n = 459)
0.933
C-statistic, women, validation cohort (n = 459)
0.944

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Indexed Aortic Valve Calcium Volume by Computed Tomography Angiography in Patients With Aortic Stenosis. JACC Cardiovasc Imaging. Published 25 October 2025. doi:10.1016/j.jcmg.2025.09.013
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Summarised from the published abstract; every number is checked against it