Prevention & lipidsCross-sectional study
Individual Variation in the Distribution of Apolipoprotein B Levels Across the Spectrum of Low-density Lipoprotein Cholesterol (LDL-C) or Non–HDL-C Levels
- Cross-sectional study
- nationally representative sample
Authors' conclusion
This study suggests that even metabolically healthy individuals may have discordantly high apoB levels relative to LDL-C or non-HDL-C levels.
Study context
- Population
- Adults not using statins, NHANES 2005–2016
- Participants
- 12,688 participants
- Outcome
- Population distribution of apoB across LDL-C or non-HDL-C levels (quantile regression); discordance between apoB and LDL-C
Main finding
As reported in the abstract
Population median apoB by LDL-C level
- Median apolipoprotein B (apoB) at LDL-C 55 mg/dL
- 49 mg/dL
- Median apoB at LDL-C 70 mg/dL
- 60 mg/dL
- Median apoB at LDL-C 100 mg/dL
- 80 mg/dL
- Median apoB at LDL-C 190 mg/dL
- 140 mg/dL
- 95% population distribution of apoB at LDL-C 100 mg/dL
- 66 mg/dL to 99 mg/dL
Observational data: associations, not effects.
Original publication
Individual Variation in the Distribution of Apolipoprotein B Levels Across the Spectrum of LDL-C or Non–HDL-C Levels. JAMA Cardiol. Published 1 August 2024. doi:10.1001/jamacardio.2024.1310
Summarised from the published abstract; every number is checked against it