Heart failure & cardiomyopathies
Individualized Family Screening for Arrhythmogenic Right Ventricular Cardiomyopathy
Authors' conclusion
Symptomatic relatives, those 20 to 30 years of age, and those with borderline ARVC have a higher probability of developing definite ARVC.
Study context
- Population
- At-risk relatives without definite arrhythmogenic right ventricular cardiomyopathy (ARVC) by 2010 task force criteria, Netherlands Arrhythmogenic Cardiomyopathy Registry123 with follow-up
- Participants
- 136 relatives
- Exposure
- Borderline ARVC vs possible ARVC
- Borderline ARVCn = 43
- Possible ARVCn = 93reference
- Outcome
- Development of definite ARVC (predictors and probability)
Methodological detailsregistry-based, external replication cohort
- Registry-based
- External replication cohort
Main finding
As reported in the abstract
Probability of developing definite ARVC
1-year probability
3-year probability
- Borderline ARVC vs Possible ARVC: P < 0.01
- Definite ARVC developed after 8.1 years (IQR: 4.2-11.4 years)
- 41 (33%)
- Symptomatic subjects had higher hazard of definite ARVC, independent of baseline phenotype
- P = 0.014
- Age 20 to 30 years had higher hazard of definite ARVC, independent of baseline phenotype
- P = 0.002
Observational data: associations, not effects.
Further findings
External replication (Italian cohort)
- Comparable results
- P > 0.05
Original publication
Individualized Family Screening for Arrhythmogenic Right Ventricular Cardiomyopathy. J Am Coll Cardiol. Published 18 May 2023. doi:10.
Summarised from the published abstract; every number is checked against it