Prevention & lipidsCohort study
Inequities in statin adherence for primary prevention of cardiovascular disease: a historical cohort study in English primary care
- Retrospective cohort study
- historical cohort
- English primary care (CPRD Aurum)
Authors' conclusion
Suboptimal statins adherence remains a significant issue and a missed opportunity to reduce CVD burden. Adherence inequities exist
Study context
- Population
- Adults aged ≥25 starting statins for primary prevention (no prior cardiovascular disease (CVD)), 2015–2019, English primary care
- Participants
- 337,990 adults
- Exposure
- Socioeconomic deprivation and ethnicity vs suboptimal statin adherence
- Outcome
- Suboptimal statin adherence (proportion of days covered (PDC)<80%)
- Follow-up
- Within one year
Main finding
As reported in the abstract
Each group vs whiteOR
Deprivation11% increase in odds
1.11(95% CI 1.08–1.13)
Black
2.00(CI 1.92–2.08)
Mixed
1.49(CI 1.41–1.56)
South-Asian
1.35(CI 1.31–1.39)
- Suboptimal adherence overall
- 32.9%
Observational data: associations, not effects.
Further findings
Effect modification by sex
- Men in deprived areas and of South-Asian ethnicity background had higher odds of suboptimal adherence
Original publication
Inequities in statin adherence for primary prevention of cardiovascular disease: a historical cohort study in English primary care. Eur J Prev Cardiol. Published 18 April 2025. doi:10.1093/eurjpc/zwaf219
Summarised from the published abstract; every number is checked against it