Cardio-oncology & otherCohort study
Infective endocarditis with or without congenital heart disease: clinical features and outcomes
- Retrospective cohort study
- nationwide registry
Authors' conclusion
Patients with CHD who develop IE exhibit distinct characteristics and improved long-term outcomes compared with patients without CHD.
Study context
- Population
- All patients with infective endocarditis in Danish nationwide registries, 1977–2021895 (6.4%) with congenital heart disease (CHD)
- Participants
- 14,040 patients
- Exposure
- Infective endocarditis (IE) with CHD vs IE without CHD
- CHDn = 895
- Outcome
- In-hospital, 1-year and 10-year mortality, and IE recurrence
Main finding
As reported in the abstract
In-hospital and 1-year mortality (cumulative incidence)
In-hospital mortality
P < 0.001
1-year mortality
P < 0.001
Observational data: associations, not effects.
Further findings
1-year mortality (cumulative incidence)
P < 0.001
Cardiac surgery during admission
P < 0.001
IE recurrence (cumulative incidence) · 10 years
- Similar between groups (13.0% and 13.9%)
- P = 0.61
CHD among patients with IE <18 years of age
- Patients with IE <18 years who had CHD
- 76%
Original publication
Infective endocarditis with or without congenital heart disease: clinical features and outcomes. Eur Heart J. Published 1 September 2024. doi:10.1093/eurheartj/ehae548
Summarised from the published abstract; every number is checked against it