Meta-analysis
Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials
- Pooled analysis of three randomised trials
- collaborative analysis
- multinational
Authors' conclusion
Among patients receiving contemporary statins, inflammation assessed by high-sensitivity CRP was a stronger predictor for risk of future cardiovascular events and death than cholesterol assessed by LDLC.
Study context
- Population
- Patients with, or at high risk of, atherosclerotic disease receiving contemporary statins in PROMINENT, REDUCE-IT or STRENGTH
- Participants
- 31,245 participants · 3 trials
- Comparison
- Highest vs lowest quartile of baseline high-sensitivity C-reactive protein (CRP) and of baseline LDL-C
- Outcome
- MACE, CV death and all-cause death by quartiles of baseline high-sensitivity CRP and LDL-C
Pooled result
As reported in the abstract
Adjusted hazard ratio (95% CI)P value
Highest CRP quartile vs Lowest CRP quartileMACE
1.31(1.20–1.43)
P < 0.0001Highest CRP quartile vs Lowest CRP quartileCV mortality
2.68(2.22–3.23)
P < 0.0001Highest CRP quartile vs Lowest CRP quartileall-cause mortality
2.42(2.12–2.77)
P < 0.0001Highest LDLC quartile vs Lowest LDLC quartileMACE
1.07(0.98–1.17)
P = 0.11Highest LDLC quartile vs Lowest LDLC quartileCV death
1.27(1.07–1.50)
P = 0.0086Highest LDLC quartile vs Lowest LDLC quartileall-cause death
1.16(1.03–1.32)
P = 0.025Original publication
Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet. Published 6 March 2023. doi:10.1016/s0140-6736(23)00215-5
Summarised from the published abstract; every number is checked against it