HypertensionCohort study
Inflammation and the long-term incidence of hypertension in women
- Prospective cohort study
Authors' conclusion
A single measure of low-grade inflammation independently associated with time-to-incident hypertension over the near- to intermediate-term, with limited prognostic value beyond 20 years.
Study context
- Population
- Normotensive Women's Health Study participants with a baseline high-sensitivity C-reactive protein (hsCRP) measurement
- Participants
- 20,224 participants
- Exposure
- hsCRP quintiles and per SD log
- Outcome
- Incident hypertension
- Follow-up
- Up to 30.9 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)
top quintile vs bottom quintile
1.33(1.25–1.41)
per SD log(hsCRP)
1.10(1.08–1.12)
Observational data: associations, not effects.
Further findings
Effect modification by age, SBP, DBP, BMI or hormone replacement therapy (HRT) use
- No effect modification
Incident hypertension by decade (landmark analyses)
- hsCRP associated in the first two decades, not beyond 20 years
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Inflammation and the long-term incidence of hypertension in women. Eur J Prev Cardiol. Published 18 August 2026. doi:10.1093/eurjpc/zwag426
Summarised from the published abstract; every number is checked against it