Inflammatory Biomarkers in Assessing Severity and Prognosis of Immune Checkpoint Inhibitor-Associated Cardiotoxicity
Authors' conclusion
In patients who develop iRCs, NER is significantly elevated at iRC onset, and higher NER correlates with greater iRC severity and higher mortality.
Study context
- Population
- Patients diagnosed with immune checkpoint inhibitor (ICI)-related cardiotoxicities (ICI-related cardiotoxicities (iRCs)), January 2019–December 2021
- Participants
- 47 patients
- Exposure
- High-grade (grade 3-4) vs low-grade (grade 1-2) ICI-related cardiotoxicity; Neutrophil-to-eosinophil ratio (NER) ≥184.33 vs lower NER
- Outcome
- Relationship of inflammatory markers (CRP, neutrophil-to-lymphocyte ratio (NLR), NER) with iRC severity and prognosis
Main finding
As reported in the abstract
NER at iRC onset, iRC severity and mortality
Odds ratio
10.77
P < 0.05
association with high-grade iRCs
Hazard ratio
2.67
P < 0.05
mortality; 36.3% increased mortality
Observational data: associations, not effects.
Further findings
Time from first ICI infusion to onset of iRCs
- Median time-to-event from first ICI infusion to iRC onset
- 35 days (IQR: 19.0-65.5 days)
Cardiac and inflammatory biomarkers at iRC onset vs baseline
- Cardiac biomarkers and inflammatory markers significantly elevated vs respective baseline values
Original publication
Inflammatory Biomarkers in Assessing Severity and Prognosis of Immune Checkpoint Inhibitor-Associated Cardiotoxicity. ESC Heart Fail. Published 28 March 2023. doi:10.
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