Heart failure & cardiomyopathies
Influence of depression trajectories in heart failure patients with preserved ejection fractions: a secondary analysis of adverse outcomes in the TOPCAT trial
Primary result · All-cause mortalityResult — go to the resultHazard ratio 2.05 95% CI 1.16–3.64Authors' conclusion
Four distinct depression trajectory patterns were identified among patients with HFpEF. Notably, patients who experienced a recurrent deterioration trajectory presented a significantly increased risk of all-cause mortality. Our findings highlight the importance of monitoring patients’ depressive symptoms over time rather than focusing on a single timepoint.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) from the TOPCAT trialparticipants from the TOPCAT trial
- Participants
- 609 patients
- Comparison
- Depression trajectory patterns and clinical outcomes
- Lown = 349reference
- Mildn = 110
- Highn = 52
- Recurrent deteriorationn = 98
Methodological detailslatent class trajectory models, multivariate Cox model
- Latent class trajectory models
- Multivariate Cox model
Primary result
All-cause mortality
Hazard ratio
2.05
95% CI 1.16–3.64
Recurrent deteriorationvs low
HR 2.05 (95% CI 1.16–3.64)
As reported in the abstract
Further findings
Distribution of depression trajectory patterns · first 3 years
Baseline characteristics
- Female
- 316 (51.9%)
- Median age
- 74 years (IQR: 66, 80)
Original publication
Influence of depression trajectories in heart failure patients with preserved ejection fractions: a secondary analysis of adverse outcomes in the TOPCAT trial. Heart. Published 15 March 2025. doi:10.
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