Coronary disease & ACSSecondary analysis
Influence of Chronic Kidney Disease on Outcomes After Paclitaxel-Coated Balloon Angioplasty for Coronary In-Stent Restenosis
- post hoc analysis of the AGENT IDE trial
- time-to-first-event and recurrent event methods
Authors' conclusion
Among patients undergoing intervention for in-stent restenosis, the benefit of DCB versus balloon angioplasty was consistent irrespective of baseline CKD status. Baseline renal function also did not influence outcomes in the recurrent event analysis.
Study context
- Population
- Patients undergoing intervention for coronary in-stent restenosis, with chronic kidney disease (CKD) (estimated glomerular filtration rate <60 mL/min per 1.73 m 2 ) and without renal impairmentpatients randomized to drug-coated balloons (DCB), 149 (25%) had CKD · CKD 149
- Participants
- 406 patients
- Comparison
- DCB vs balloon angioplasty
- Primary endpoint
- Target lesion failure:
- Ischemia-driven target lesion revascularization (TLR)
- Target vessel myocardial infarction
- Cardiac death
- Follow-up
- 2 years
Primary result
As reported in the abstract
DCB vs balloon angioplastyHazard ratio (95% CI)
patients with CKD: 23.6% versus 30.0%
0.70(0.35–1.39)
patients without CKD: 28.1% versus 34.9%
0.74(0.52–1.05)
Further findings
Baseline characteristics of CKD patients
- mean estimated glomerular filtration rate (CKD)
- 47.3±9.2
- Older, greater multivessel disease and congestive heart failure than those without CKD
- No differences in clinical presentation, Mehran in-stent restenosis patterns or technical success
Recurrent events analysis
- Effect of DCB not influenced by baseline renal function
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Influence of Chronic Kidney Disease on Outcomes After Paclitaxel-Coated Balloon Angioplasty for Coronary In-Stent Restenosis. Circ Cardiovasc Interv. Published 17 September 2026. doi:10.1161/circinterventions.126.016978
Summarised from the published abstract; every number is checked against it