Acute cardiac care & resuscitation
Influence of microaxial flow pump level on haemolysis and kidney injury in patients with cardiogenic shock: a retrospective study
Main finding · AKIResult — go to the resultAdjusted risk ratio 3.31 95% CI 1.67–6.58Authors' conclusion
Higher mAFP levels are significantly associated with higher PFHb levels, which may increase the risk of AKI in patients treated with mAFP alone.
Study context
- Population
- Patients aged ≥18 years with cardiogenic shock who underwent microaxial flow pumps (mAFP) between December 2019 and March 2025 at Saiseikai Kumamoto Hospital, Japananalysed separately by support type · mAFP alone 49 · V-A ECMO plus mAFP 111
- Participants
- 160 patients
- Exposure
- Association between flow pump level, cumulative plasma-free haemoglobin (PFHb) exposure, and acute kidney injury (AKI)
- mAFP alonen = 49
- V-A ECMO plus mAFPn = 111
- Outcome
- AKI
Methodological detailsconsecutive patients, single centre (Saiseikai Kumamoto Hospital, Japan)
- Consecutive patients
- Single centre (Saiseikai Kumamoto Hospital, Japan)
Main finding
AKI
Adjusted risk ratio
3.31
95% CI 1.67–6.58
P < 0.001
High flow pump level ≥ P8 for 24 h or longer
adjusted risk ratio 3.31 (95% CI 1.67–6.58); P < 0.001
As reported in the abstract
- Higher cumulative PFHb exposure associated with increased risk of AKI in the mAFP-alone subgroup
- adjusted P for spline = 0.03
Observational data: associations, not effects.
Further findings
PFHb levels by mAFP pump level (mAFP alone)
- Higher mAFP pump levels significantly associated with higher PFHb levels
- adjusted P for spline < 0.001
- Association not observed in patients treated with V-A ECMO plus mAFP
Original publication
Influence of microaxial flow pump level on haemolysis and kidney injury in patients with cardiogenic shock: a retrospective study. Eur Heart J Acute Cardiovasc Care. Published 7 August 2026. doi:10.
Summarised from the published abstract; every number is checked against it