Influence of Obesity on Coronary Artery Disease and Clinical Outcomes in the ADVANCE Registry
Authors' conclusion
Patients with obesity in the ADVANCE registry were less likely to have anatomically obstructive CAD by cardiac computed tomography angiography but had a similar degree of physiologically significant CAD by FFRCT and similar rates of adverse events.
Study context
- Population
- Patients evaluated for clinically suspected coronary artery disease (CAD) with >30% stenosis on cardiac CT angiography (ADVANCE Registry)
- Participants
- 5,014 patients
- Exposure
- Obese vs overweight vs normal body mass index (BMI)
- Normaln = 2,166reference
- Overweightn = 1,883
- Obesen = 965
- Outcome
- Association of BMI with CAD (CT angiography, FFRCT) and clinical outcomes
Main finding
As reported in the abstract
Obstructive coronary stenosis
Positive FFRCT
| Outcome | Normal | Overweight | Obese |
|---|---|---|---|
| Coronary volume-to-myocardial mass ratio | 26.3 | 24.8 | 23.7 |
Observational data: associations, not effects.
Further findings
MACE (adjusted)
- Risk of MACE similar regardless of BMI after adjustment
- all P>0.05
Original publication
Influence of Obesity on Coronary Artery Disease and Clinical Outcomes in the ADVANCE Registry. Circ Cardiovasc Imaging. Published 16 May 2023. doi:10.
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